Use of virus-like recombinant protein biosomes in prevention or treatment of lesions in acidic environments

• Main Authors: LYU WANLIANG, BAO CHUNJIE, DUAN JIALUN
• Format: Patent
• Language: Chinese; English
• Published: 02.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR CHEMICAL WORKING-UP; VINEGAR; WINE

The invention discloses an application of a virus-like recombinant protein biosome in preventing or treating a focus in an acid environment. Experiments prove that the prepared virus-like recombinant protein biosome has pH responsiveness and can respond to an acidic or weakly acidic environment, and a virus-like recombinant protein biosome gene editing system constructed according to the virus-like recombinant protein biosome plays a gene therapy effect in breast cancer tumors; the therapeutic effect of inhibiting breast cancer tumor proliferation is achieved; the virus-like recombinant protein biosome gene silencing system constructed according to the virus-like recombinant protein biosome plays a gene therapeutic effect in rheumatoid arthritis, and has therapeutic effects of inhibiting inflammatory factors and relieving inflammation. The gene therapy effect is verified in vitro and in vivo, efficient and low-toxicity acid focus targeted gene therapy is achieved, and the gene has important scientific signifi