Nalloxone formulations for sublingual and/or buccal administration

• Main Author: MCCARTY, JOHN, A
• Format: Patent
• Language: Chinese; English
• Published: 02.02.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are liquid, gel, and semi-solid compositions containing a naloxone base, or an isomer or derivative thereof, and one or more non-aqueous solvents, and optionally a viscosity modifier. Also provided are methods of treating an individual exhibiting a symptom of respiratory depression associated with known or suspected opioid excess comprising administering a liquid, gel or semi-solid formulation comprising a solution of a naloxone base, or an isomer or derivative thereof in one or more non-aqueous solvents. 提供了含有纳洛酮碱、或其异构体或衍生物，以及一种或多种非水溶剂，和任选的黏度调节剂的液体、凝胶和半固体组合物。还提供了治疗表现出与已知或疑似阿片样物质过量相关的呼吸抑制的症状的个体的方法，所述方法包括施用含有纳洛酮碱、或其异构体或衍生物在一种或多种非水溶剂中的溶液的液体、凝胶或半固体制剂。