RNAi nanoparticles and methods of use thereof in agriculture

The present invention provides a nanoparticle comprising: (a) an amphiphilic copolymer comprising an ionizable polymer covalently bound to a hydrophobic domain; and a polynucleotide comprising from 60 to 500 nucleobases. Compositions comprising the nanoparticles of the invention and methods of using...

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Bibliographic Details
Main Authors SADOT MUZKA NADJA, PESKY, ZBIGNIEW, L, SHOSEYOV, ODED, AVITAL AMIT, SCHROEDER AVI
Format Patent
LanguageChinese
English
Published 30.01.2024
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
PEST REPELLANTS OR ATTRACTANTS
PLANT GROWTH REGULATORS
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF
TRAPPING
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Summary:The present invention provides a nanoparticle comprising: (a) an amphiphilic copolymer comprising an ionizable polymer covalently bound to a hydrophobic domain; and a polynucleotide comprising from 60 to 500 nucleobases. Compositions comprising the nanoparticles of the invention and methods of using the same are further provided. 本发明提供了一种纳米颗粒，其包括:(a)两亲性共聚物，所述两亲性共聚物包括共价结合到疏水结构域的可电离聚合物；和包括60至500个核碱基的多核苷酸。进一步提供了包括本发明的纳米颗粒的组合物以及其使用方法。
Bibliography:Application Number: CN202280022643