Methods of treating tumors with anti-PD-1 antibodies

• Main Authors: GEESE WILLIAM J, EDWARDS, RICHARD, GREENAWALT DANIELLE M
• Format: Patent
• Language: Chinese; English
• Published: 30.01.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides a method for treating a subject having a tumor, the method comprising administering to the subject an antibody, or an antigen-binding portion thereof, that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity. In some embodiments, the tumor is derived from non-small cell lung cancer (NSCLC). In some embodiments, the tumor expresses programmed death ligand 1. In some embodiments, the subject carries a wild type STK11 gene. 本公开提供用于治疗患有肿瘤的受试者的方法，该方法包括对受试者施用特异性结合程序性死亡-1(PD-1)受体并抑制PD-1活性的抗体或其抗原结合部分。在一些实施方案中，该肿瘤源自非小细胞肺癌(NSCLC)。在一些实施方案中，该肿瘤表达程序性死亡配体1。在一些实施方案中，该受试者携带野生型STK11基因。