Polygonatum polysaccharide composition for treating ulcerative colitis and preparation method of polysaccharide composition

• Main Authors: CAI XUEFEI, LI TINGZHAO, CHEN LIANG, PENG BO, GAN XIAONA, LI BO
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2024
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

A method of preparing a polygonatum polysaccharide composition is provided. The method comprises performing a first extraction of a polygonatum sibiricum material to obtain a first residue; performing a second extraction of the first residue to obtain a second residue; performing a third extraction of the second residue to obtain a supernatant, and precipitating the supernatant with a solvent to obtain a crude polysaccharide; eluting the crude polysaccharide with a first eluent to obtain a first eluent; and performing a filtration of the first eluent. Also provided are a polygonatum polysaccharide composition obtained by the method, an oral composition comprising the polygonatum polysaccharide composition, use of the polygonatum polysaccharide composition in the preparation of a medicament for treating ulcerative colitis (UC) in a subject, and a method of treating UC in a subject. The Polygonatum sibiricum polysaccharide composition comprises, consists essentially of, or consists of, isolated polysaccharides