Application of calcium-rich montmorillonite/sodium alginate artificial particles in preparation of oral medicines

• Main Authors: ZHANG BOXIANG, YANG YATING, WEN YAQI
• Format: Patent
• Language: Chinese; English
• Published: 26.01.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of drug carriers, in particular to application of calcium-rich montmorillonite/sodium alginate artificial bead particles in preparation of oral drugs, and particularly relates to application of the calcium-rich montmorillonite/sodium alginate artificial bead particles as a norfloxacin carrier in preparation of the oral drugs. The drug loading capacity is optimized within the pH value range of 1-11, it is ensured that artificial particles are not disintegrated, and drug desorption is reduced to the maximum extent; an escherichia coli antibacterial research is carried out on the bacillus subtilis, and a positive result is obtained; the clay-based norfloxacin/montmorillonite beads prepared by the invention show stability, disintegration resistance and minimum drug desorption, so that the clay-based norfloxacin/montmorillonite beads are suitable for being used as oral pills. 本发明涉及药物载体技术领域，具体是一种富钙蒙脱石/海藻酸钠人造珠颗粒在制备口服药物中的应用，具体为：富钙蒙脱石/海藻酸钠人造珠颗粒作为诺氟沙星载体应用于口服药物制备中。本发明在pH值为1～1