Anti-dLL3 antibody-drug conjugates

• Main Authors: CHEN XIN, LORENZ IVO, RUDIN, CYNTHIA, POIRIER JOHN T, LOUIS JOHN, MATSUNAGA HIRONORI, ANDREW DAVID, KHAN ASIF
• Format: Patent
• Language: Chinese; English
• Published: 19.01.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The purpose of the present invention is to provide an antibody-drug conjugate of an antibody that binds to DLL3 and a drug having antitumor activity, a pharmaceutical composition that contains the antibody-drug conjugate and has a therapeutic effect on tumors, a method for treating tumors using the antibody-drug conjugate or the pharmaceutical composition, and the like. The present invention provides an antibody-drug conjugate of an antibody that binds to DLL3 and a drug having anti-tumor activity, a pharmaceutical composition comprising the antibody or the antibody-drug conjugate, and a method for treating a tumor. 本发明的目的是提供与DLL3结合的抗体和具有抗肿瘤活性的药物的抗体-药物缀合物、包含所述抗体-药物缀合物并且具有对肿瘤的治疗效果的药物组合物、用于使用所述抗体-药物缀合物或所述药物组合物治疗肿瘤的方法等。本发明提供了与DLL3结合的抗体和具有抗肿瘤活性的药物的抗体-药物缀合物、包含所述抗体或所述抗体-药物缀合物的药物组合物、和用于治疗肿瘤的方法。