Application of LAYN molecule in prediction of immune cell infiltration, immune checkpoint molecular expression level and T cell depletion in tumor

• Main Authors: XIAO SHUXIU, LU LILI, LIN ZHIYUAN, GU JIANYING, ZHOU YUHONG
• Format: Patent
• Language: Chinese; English
• Published: 19.01.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses application of LAYN molecules in prediction of immune cell infiltration, immune checkpoint molecular expression level and T cell depletion in tumors. The method comprises the following steps: firstly, acquiring a clinical HCC patient tissue specimen and PBMC, and revealing the relationship between the LAYN expression level and immune cell infiltration and immune molecule expression in an HCC tumor microenvironment, and the influence on the survival, proliferation, accumulation and immune response characteristics of depleted cells; meanwhile, an HCC tissue chip is utilized to analyze the relationship between the LAYN expression level and patient prognosis. The invention systematically studies the relationship between LAYN in human and animal liver cancer and immune cell infiltration and immune checkpoint molecular expression level in tumor microenvironment as well as depletion T cell phenotype and effector function for the first time, so as to explore the evaluation of the prognosis of