Antibody specifically binding to IGF1R and application thereof

• Main Authors: LIU SHUANG, WANG TAO, LIU YANSHUANG, XIE HONGMEI, LIANG YANGQIU, JI ZHONGSHENG, JIN LEI
• Format: Patent
• Language: Chinese; English
• Published: 19.01.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The invention belongs to the technical field of biological immunity, and particularly relates to an antibody specifically bound with IGF1R or an antigen binding fragment thereof, in particular to a fully human anti-IGF1R monoclonal antibody and application thereof. The present application also relates to bispecific or multispecific molecules, immunoconjugates, pharmaceutical compositions, kits comprising the antibodies or antigen binding fragments thereof, and uses thereof. 本申请属于生物免疫技术领域，具体涉及特异性结合IGF1R的抗体或其抗原结合片段，尤其涉及全人源抗IGF1R单克隆抗体及其应用。本申请还涉及包含所述抗体或其抗原结合片段的双特异性或多特异性分子，免疫缀合物，药物组合物，试剂盒以及它们的用途。