Combination of fosfomycin and colistin for resisting biofilm-related bacterial infections

• Main Authors: BONCOMPANI, STEFANO, PARDONI, GIANNI, MIDGLEY MATTHEW, GHIANI TOMMASO, PALEKOC, LJUBOMIR, VAILATI SILVIA, ROSSOLINI GIAN MARIA, COLUMBO, DANILO, ANTONELLI, ALESSANDRO, AIZAR NEHAL
• Format: Patent
• Language: Chinese; English
• Published: 16.01.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a synergistic pharmacological anti-biofilm combination of colistin and fosfomycin for use in the treatment of bacterial infections caused by biofilm-forming pathogens selected from the group consisting of Acinetobacter baumannii, Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Klebsiella pneumoniae strains, preferably in the biofilm growth phase, the present invention relates to the treatment of respiratory diseases, in particular infections associated with respiratory diseases, such as chronic respiratory diseases including CF, NCFB and COPD, especially in hospitalized patients. 本发明涉及粘菌素和磷霉素的协同药理抗生物膜联合，其用于治疗由优选处于生物膜生长期的选自鲍曼不动杆菌、铜绿假单胞菌、嗜麦芽窄食单胞菌和肺炎克雷伯菌菌株的形成生物膜的病原体引起的细菌感染，特别是与呼吸道疾病相关的感染，诸如包括CF、NCFB和COPD在内的慢性呼吸道疾病，尤其是在住院患者中。