Ex vivo BITE activated T cells

• Main Authors: BALLESTEROS NOBELL JUAN ANTONIO, HERNANDEZ CAMPO PILAR, MARTINEZ LOPEZ, JOAQUIN, BENNET, TRISHA, ANN, PRIMO RAMOS DANIEL, GOMEZ GONZALEZ CRISTINA, ROBLES MARTIOS, ALICIA, GOLOSHATIG GUILLEN, JURIAN
• Format: Patent
• Language: Chinese; English
• Published: 02.01.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

By optimizing the proximity between the target cells and the immune effector cells, the production and identification of efficient immune effector cells can be enhanced in the aspect of target cell killing activity. The cancer killing T cells described herein can provide efficient treatment for a variety of cancer types, such as solid cancers, hematological cancers, and metastatic forms thereof. Provided herein are ex vivo methods of generating cancer killing T cells, compositions comprising such immune cells; methods of using the cells, methods of selecting optimal agents for enhancing killing activity of target cells, methods of selecting optimized immune cells, and methods of assessing patient responsiveness to other cancer treatments using the methods. 通过优化靶细胞和免疫效应细胞之间的接近度，在靶细胞杀伤活性方面可以增强高效免疫效应细胞的产生和鉴定。本文所述的癌症杀伤T细胞可以为多种癌症类型例如实体癌症，血液癌症及其转移形式提供高效治疗。本文提供了产生癌症杀伤T细胞的离体方法，包含此种免疫细胞的组合物；使用所述细胞的方法，选择用于增强靶细胞杀伤活性的最佳试剂的方法，选择优化的免疫细胞的方法和使用该方法评估患者对其他癌症治疗的应答性的方法。