Modified ribonucleic acids and uses thereof

Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising N4-acetylcytidine and/or 5-hydroxymethyluridine, and a polyribonucleotide comprising the same. Also provided herein are compositions comprising the polyribonucleotides of the present disclosure, as well as methods of ma...

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Bibliographic Details
Main Authors BACHMANN KATI, KEVINEY MATTHEW, WEBSTER ERIC, QUINN JORDAN, EROSHENKO NIKOLAY, DHAR NITIN
Format Patent
LanguageChinese
English
Published 29.12.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising N4-acetylcytidine and/or 5-hydroxymethyluridine, and a polyribonucleotide comprising the same. Also provided herein are compositions comprising the polyribonucleotides of the present disclosure, as well as methods of making and using the same. 本文公开了一种修饰的核糖核苷酸，其包含含有N4-乙酰胞苷和/或5-羟甲基尿苷的核苷，以及包含其的多核糖核苷酸。本文还提供了包含本公开的多核糖核苷酸的组合物，以及其制备和使用方法。
Bibliography:Application Number: CN202280032863