Phthalazinone derivatives as NLRP3 inflammasome inhibitors

• Main Authors: UEHLICH DANIEL, LANCANFI MASSIMO, CANELLAS ROMAN SERGIO, VAN ODENBOS NICOLAS, VAN GOOL, MICHIEL, LUC, MARIA, DIGUES VAZQUEZ ANTONIO
• Format: Patent
• Language: Chinese; English
• Published: 22.12.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present disclosure provides novel compounds useful as inhibitors of NLRP3 inflammasome production wherein such compounds are as defined by a compound of Formula (I) # imgabs0 # wherein R1, R2 and R3a and R3b are as defined in the specification, and wherein these compounds are useful as agents, f...