Phthalazinone derivatives as NLRP3 inflammasome inhibitors

• Main Authors: UEHLICH DANIEL, LANCANFI MASSIMO, CANELLAS ROMAN SERGIO, VAN ODENBOS NICOLAS, VAN GOOL, MICHIEL, LUC, MARIA, DIGUES VAZQUEZ ANTONIO
• Format: Patent
• Language: Chinese; English
• Published: 22.12.2023
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present disclosure provides novel compounds useful as inhibitors of NLRP3 inflammasome production wherein such compounds are as defined by a compound of Formula (I) # imgabs0 # wherein R1, R2 and R3a and R3b are as defined in the specification, and wherein these compounds are useful as agents, for example, in the treatment of diseases or conditions associated with NLRP3 inflammasome activity. 本公开提供了用作NLRP3炎性小体产生抑制剂的新型化合物，其中此类化合物如式(I)的化合物所定义，#imgabs0#其中R1、R2和R3a和R3b如本说明书中所定义，并且其中这些化合物能够用作例如在治疗与NLRP3炎性小体活性相关的疾病或病症中使用的药剂。