Method for preparing isoindoline-1-ketone from sulfoxide ylide

The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for preparing isoindoline-1-ketone from sulfoxide ylide. O-alkenyl benzamide and sulfoxide ylide are used as raw materials, dichloro (pentamethylcyclopentadienyl) iridium...

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Bibliographic Details
Main Authors YANG QI, YANG HAN, CHENG PEIDONG, LI MIAO, SUN SONG, YAO YANG, BAI JUNXUE
Format Patent
LanguageChinese
English
Published 22.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to the fields of medicine, organic chemical industry and fine chemical industry, in particular to a method for preparing isoindoline-1-ketone from sulfoxide ylide. O-alkenyl benzamide and sulfoxide ylide are used as raw materials, dichloro (pentamethylcyclopentadienyl) iridium (III) dimer or dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer is used as a catalyst, organic acid is used as an additive, dichloromethane, 1, 2-dichloroethane or hexafluoroisopropanol and the like are used as a solvent, a reaction is carried out for 12 hours at the temperature of 50-100 DEG C, and the product is obtained. And a series of functionalized isoindoline-1-ketone compounds can be obtained at a relatively high yield through simple post-treatment. The o-alkenyl benzamide of various substituent groups and the sulfoxide ylide connected with various substituent groups can well participate in the reaction to obtain the corresponding functionalized isoindoline-1-ketone compound. 本发明涉及医药、有机化工及精细化工领域，具
Bibliography:Application Number: CN202311223564