AAV2 affinity agents

• Main Authors: SCANLON TIMOTHY, KETT, WILLIAM, NDONG CHRISTOPHER, VALENTINI SILVIA, KEARNS KENNETH, BELK JONATHAN
• Format: Patent
• Language: Chinese; English
• Published: 15.12.2023
• Subjects: PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; SEPARATION; TRANSPORTING

The present disclosure relates to the field of chromatography and more particularly to novel affinity ligands and affinity agents suitable for the isolation of adeno-associated viruses (AAV). Thus, the present disclosure encompasses the affinity ligands themselves, chromatographic separation matrices (affinity agents) comprising the affinity ligands according to the present disclosure, and processes of AAV separation, particularly AAV serotype 2 (AAV2) separation, where the ligands according to the present disclosure are used. 本公开涉及色谱领域，并且更具体地涉及适用于分离腺相关病毒(AAV)的新型亲和配体和亲和剂。因此，本公开涵盖亲和配体本身、包含根据本公开的亲和配体的色谱分离基质(亲和剂)，以及AAV分离，特别是AAV血清型2(AAV2)分离的过程，其中使用根据本公开的配体。