Compounds for activating constant natural killer t-cells and methods for eliminating inflammatory senescence cells

• Main Authors: DUNCTON MATTHEW, KALE AMIT, BABINSKY TINA, AWITZ NATHAN G, DENNY JOSEPH, S.ARMSTRONG, SHAH ANKUR, MANSUKANI RAVI, HATANO ROBERT, GALLOWAY, JOHN
• Format: Patent
• Language: Chinese; English
• Published: 12.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Compounds for activating constant natural killer T cells (iNKT) are provided. Compounds according to certain embodiments activate iNKT cells and induce an increase in the production of one or more cytokines such as IFN [gamma], IL-2, IL-4, IL-6, and TNF [alpha]. In some embodiments, activated iNKT cells are used to selectively reduce the presence of inflammatory senescence cells or eliminate inflammatory senescence cells, such as senescence cells with an inflammatory secretory group (SASP). Also described are methods of activating iNKT cells by contacting the iNKT cells with an amount of the compound and selectively reducing the presence of senescent cells or eliminating senescent cells with the activated iNKT cells. Compositions for carrying out the methods are also described. 提供了用于激活恒定自然杀伤T细胞(iNKT)的化合物。根据某些实施方式的化合物激活iNKT细胞并诱导一种或多种细胞因子如IFNγ、IL-2、IL-4、IL-6和TNFα的产生的增加。在一些实施方式中，激活的iNKT细胞用于选择性地减少炎性衰老细胞的存在或消除炎性衰老细胞，如具有炎性分泌组(SASP)的衰老细胞。还描述了通过将iNKT细胞接触一定量的所述化合物激活iNKT细胞并用激活的iNKT细胞选择性地减少衰老细胞的存在或消除衰老细胞的方法。还描述了用于实施所述方法