Deuterated heterocyclic compound as well as preparation method and application thereof

According to the preparation method of the deuterated heterocyclic compound, deuteration is introduced in the early stage of the synthesis route of the compound A, the conversion step of expensive raw materials in the later stage of the synthesis route is reduced, the synthesis cost of the compound...

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Bibliographic Details
Main Authors CHEN YUELEI, HE DARONG, WU HAO, HU ZHIGANG, ZHAO HAOYING, HE YONG
Format Patent
LanguageChinese
English
Published 08.12.2023
Subjects
APPARATUS THEREFOR
CHEMISTRY
DERIVATIVES THEREOF
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:According to the preparation method of the deuterated heterocyclic compound, deuteration is introduced in the early stage of the synthesis route of the compound A, the conversion step of expensive raw materials in the later stage of the synthesis route is reduced, the synthesis cost of the compound A is remarkably reduced, the yield is high, the process is simple, and the raw materials are easy to obtain. On the basis, the inventor completes the invention. 本发明提供一种氘代杂环化合物的制备方法，该方法在化合物A的合成路线前期即引入氘代，有利于减少合成路线后期昂贵原料的转化步骤，显著降低化合物A的合成成本，且产率高、工艺简单原料易得。在此基础上，发明人完成了本发明。
Bibliography:Application Number: CN202210622698