Substituted pyridazine-3-carboxamide compounds as TYK2 inhibitors

The present invention provides a pyridazine-3-carboxamide compound of general formula (I), or a pharmaceutically acceptable salt, enantiomer, diastereoisomer, raceme, solvate, hydrate, polymorph, prodrug or isotope variant thereof. The invention further provides a pharmaceutical composition containi...

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Bibliographic Details
Main Authors ZHONG WENHE, LEI ZENGRONG, LU JIELIAN, DENG DAIGUO
Format Patent
LanguageChinese
English
Published 08.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a pyridazine-3-carboxamide compound of general formula (I), or a pharmaceutically acceptable salt, enantiomer, diastereoisomer, raceme, solvate, hydrate, polymorph, prodrug or isotope variant thereof. The invention further provides a pharmaceutical composition containing the compound, a preparation method of the pharmaceutical composition and application of the pharmaceutical composition in treatment or prevention of TYK2 kinase mediated diseases. # imgabs0 # 本发明提供了通式(I)的哒嗪-3-甲酰胺化合物，或其药学上可接受的盐、对映异构体、非对映异构体、外消旋体、溶剂合物、水合物、多晶型、前药或同位素变体。本发明还提供了包含所述化合物的药物组合物，其制备方法及其在治疗或预防TYK2激酶介导的疾病中的用途。#imgabs0#
Bibliography:Application Number: CN202310667551