Preparation method of acetyl L-carnitine hydrochloride

• Main Authors: YAN SHUYI, ZHANG YAN, XIANG TING, XU GUOSHAI, XIONG HUANWEN, XIONG FENG, XU YONG
• Format: Patent
• Language: Chinese; English
• Published: 08.12.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention belongs to the technical field of pharmaceutical chemicals, and particularly discloses a preparation method of acetyl L-carnitine hydrochloride. The method comprises the following steps: taking L-carnonitrile as a raw material, adding glacial acetic acid, water, potassium permanganate and sodium nitrite into the L-carnonitrile, reacting for 1-4 hours at 40-50 DEG C, dropwise adding acetyl chloride, heating to 118-130 DEG C, reacting for 1-4 hours, and concentrating under reduced pressure to obtain acetyl L-carnitine amide chloride; adding absolute ethyl alcohol and a certain amount of 36 wt% concentrated hydrochloric acid, reacting for 0.5-2.5 hours at the temperature of 20-60 DEG C, cooling, crystallizing and filtering to obtain an acetyl L-carnitine hydrochloride ethanol solution; adding absolute ethyl alcohol until the mass percent concentration of ethyl alcohol in the ethyl alcohol solution reaches 85%-95%, heating for dissolving, cooling for crystallization, filtering and vacuum drying to o