Microfiber collagen hemostatic material as well as preparation method and application thereof

• Main Authors: CHANG, HONG-SUNG, BAO LIUJUN, XU SONGCHENG
• Format: Patent
• Language: Chinese; English
• Published: 08.12.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention discloses a preparation method of a microfiber collagen hemostatic material, which comprises the following steps: introducing anisotropic shearing force and ultrasonic cavitation in a self-assembly process, destroying a hydrogel locking bracket among collagen molecules by utilizing mechanical disturbance, instantly reinforcing the acting force among fiber units, and separating out microfiber collagen; the invention also provides a preparation method of the microfiber collagen hemostatic material, and the microfiber collagen hemostatic material with controllable fiber size can be prepared by synergistically regulating and controlling a collagen self-assembly preparation process. The invention also provides a microfiber collagen hemostatic material and an application thereof, the microfiber collagen hemostatic material has a human tissue consistent D period and a larger specific surface area, and can efficiently and rapidly adhere platelets, trigger a blood coagulation mechanism and realize a rapi