Betamethasone dipropionate composition as well as nano freeze-drying agent and preparation method thereof

• Main Authors: CHEN JIAN, FANG YANDONG, SHEN ZHENG, YANG JINGHUA, SUN BOWANG, GE JILONG
• Format: Patent
• Language: Chinese; English
• Published: 05.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a betamethasone dipropionate composition as well as a nanocrystalline freeze-drying agent and a preparation method thereof, the betamethasone dipropionate composition is prepared from betamethasone dipropionate, a specific surfactant and a high-molecular polymer, the betamethasone dipropionate composition and water are prepared into a suspension, the suspension is ground by a wet medium to obtain a nano suspension, and the nano suspension is freeze-dried to obtain the betamethasone dipropionate nanocrystal freeze-drying agent. The betamethasone dipropionate nanocrystal freeze-drying agent is prepared by taking betamethasone dipropionate as a raw material and solidifying the betamethasone dipropionate nanocrystal through a freeze-drying technology, the betamethasone dipropionate nanocrystal freeze-drying agent has extremely high saturation solubility, an experiment on a psoriasis mouse model shows that the betamethasone dipropionate nanocrystal freeze-drying agent has an excellent effect