Gel material based on oleanolic acid and isoniazide medicine as well as preparation method and application of gel material

• Main Authors: LIU JIAMENG, LUO XUZHONG, CHEN YILAN, HU YUQIAO, JIANG WENTING, JIA XINJIAN, XU LU, LIU HAIDONG, WU ZIJING, ZHANG XIANGQIN, TANG JIE, ZHONG YUHONG, XIE YINLONG, LIAO LIEQIANG, ZENG ZHIJUN
• Format: Patent
• Language: Chinese; English
• Published: 05.12.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of material chemistry, and discloses a gel material based on oleanolic acid and isoniazide drugs and a preparation method and application thereof.The gel material is prepared through the following steps that firstly, a certain amount of isoniazide and oleanolic acid are mixed according to a certain molar ratio and dissolved in a certain volume of an ethanol solution, and an ethanol solution is obtained; and removing the ethanol in a reduced pressure distillation manner. The method has the advantages that the method is simple and easy to implement, and the prepared in-situ gel material is good in biocompatibility and can serve as a carrier to serve as a drug delivery system; in addition, the used gel is composed of oleanolic acid with an anti-cancer effect and isoniazide drug small molecules with an anti-inflammatory effect, and the pharmacological activity of the gel has an auxiliary treatment effect on diseases, so that the synergistic treatment effect is achieved