Preparation and application of gel material based on metformin and oleanolic acid medicine

• Main Authors: LIU TONGJIA, ZHONG JINLIAN, XUE YUXUAN, LUO XUZHONG, CHEN YILAN, HU YUQIAO, JIANG WENTING, JIA XINJIAN, LIU HAIDONG, LUO HAIQING, DENG WENTING, TANG JIE, XIE YINLONG, LIAO LIEQIANG, LIU HUIJIN, ZENG ZHIJUN
• Format: Patent
• Language: Chinese; English
• Published: 05.12.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses preparation and application of a gel material based on metformin and an oleanolic acid drug, belongs to the field of material chemistry, and relates to a biomedical material.The gel material is prepared through the following steps that firstly, natural drug micromolecule metformin and oleanolic acid are selected to be mixed according to a certain molar ratio and dissolved in a certain volume of ethanol solvent, and a mixture is obtained; ethyl alcohol is removed in a reduced pressure distillation mode, and the organic salt composed of oleanolic acid and metformin is obtained. The method provided by the invention is simple and easy to implement, the prepared low-molecular-weight supramolecular gel material formed by self-assembly of the two molecules has good biocompatibility in a life body, is easy to degrade and can be used as a carrier as a drug delivery system, and in addition, the pharmacological activity of the supramolecular gel material has an adjuvant therapy effect on diseases