Modified plasma coagulation factor VIII and methods of use thereof

The present application describes a modified hum1. An Factor VIII polypeptide, which polypeptide has an enhanced Factor VIII activity. In some embodiments, the modified human factor VIII polypeptides comprise one or more amino acid substitutions at positions A20, T21, F57, L69, I80, L178, R199, H212...

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Bibliographic Details
Main Authors YU DAOZHAN, WANG QIZHAO
Format Patent
LanguageChinese
English
Published 01.12.2023
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present application describes a modified hum1. An Factor VIII polypeptide, which polypeptide has an enhanced Factor VIII activity. In some embodiments, the modified human factor VIII polypeptides comprise one or more amino acid substitutions at positions A20, T21, F57, L69, I80, L178, R199, H212, I215, R269, I310, L318, S332, R378, I610, and/or I661. Such polypeptides and viral vectors encoding these polypeptides can be used in the treatment of FVIII deficiency conditions, such as hemophilia A. 本申请描述了修饰的hum1.an因子VIII多肽，所述多肽具有增强的因子VIII活性。在一些实施方式中，所述修饰的人因子VIII多肽在位置A20、T21、F57、L69、I80、L178、R199、H212、I215、R269、I310、L318、S332、R378、I610和/或I661处包含一个或多个氨基酸取代。这种多肽和编码这些多肽的病毒载体可以用于治疗FVIII缺乏症，例如甲型血友病。
Bibliography:Application Number: CN202180096784