Application of TLR4 inhibitor in preparation of medicine for relieving gastrointestinal toxicity caused by sorafenib

• Main Authors: XU YANING, XIE ZHIYONG, HONG YANJUN
• Format: Patent
• Language: Chinese; English
• Published: 01.12.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of a TLR4 inhibitor in preparation of a medicine for relieving gastrointestinal toxicity caused by sorafenib, and relates to the field of biological medicine. The TLR4 inhibitor has an effect of relieving gastrointestinal toxicity induced by sorafenib, can callback slow weight increase of mice caused by sorafenib, relieves intestinal mucosa injury of the mice caused by sorafenib, and relieves intestinal oxidative stress caused by sorafenib. 本发明公开了TLR4抑制剂在制备缓解索拉非尼所致胃肠道毒性的药物中的应用，涉及生物医药领域。TLR4抑制剂对索拉非尼诱导的胃肠道毒性具有缓解作用，能够回调索拉非尼导致的小鼠体重增加缓慢，缓解索拉非尼导致的小鼠肠黏膜损伤，减轻索拉非尼导致的肠道氧化应激。