Hematopoietic growth factor depleted vaccine compositions for treating inflammatory diseases

• Main Authors: PEREZ MARTINEZ DAVID, LOPEZ MEDANILLA, ANTONIO, PEREJANZ KATHERINE, GALVEZ VALCARCEL JUAN RAMON, LAGO DAVILA ALBERTO BELEN, LEDENNARANJE, NIKOLAUS, SAAVEDRA HERN ¨ ¢ NDEZ, DANIEL, SUAREZ FORMIGO GERARDO M, ROJAS DORANTES GERTRUDIS, SALEVASOSA ANDREI, FUENTES MORALES DAVID, OTERO ALFARO OCTAVIO
• Format: Patent
• Language: Chinese; English
• Published: 24.11.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to the fields of biotechnology and medicine. In particular, it describes therapeutic vaccine compositions capable of producing an autoimmune response against hematopoietic growth factors, such as G-SCF and/or GM-CSF bound to other molecules or fragments thereof by chemical conjugation or fusion. Such vaccine compositions are useful in the treatment of inflammatory diseases, especially diseases in which an increase in circulatory neutrophil pathology occurs. 本发明涉及生物技术和医学领域。特别地，其描述了治疗性疫苗组合物，所述治疗性组合物能够产生针对造血生长因子诸如通过化学缀合或融合与其它分子或其片段结合的G-SCF和/或GM-CSF的自身免疫反应。此类疫苗组合物可用于治疗炎性疾病，尤其是其中出现循环中性粒细胞病理性增加的疾病。