Method for culturing bone marrow mesenchymal stem cells and application of bone marrow mesenchymal stem cells in treatment of temporomandibular arthritis

• Main Authors: JIANG HAITAO, LUO ZILING, CHENG JIAO, LUO XIANGYOU, CHEN XING, TANG QIUYU, MITSUSHIRO, ZHENG DEXIN
• Format: Patent
• Language: Chinese; English
• Published: 24.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention belongs to the technical field of biological medicines, and particularly relates to application of PTH induced cultured bone marrow mesenchymal stem cells (BMSC) in preparation of a medicine for treating temporomandibular arthritis. The invention has the beneficial effects that PTH can significantly improve the multiplication capacity of BMSC and improve the tolerance of BMSC to active oxygen and hypoxia, the bone marrow mesenchymal stem cells induced and cultured by PTH have the potential of being developed into drugs for treating temporomandibular arthritis, and finally the treatment effect of BMSC on TMJOA is enhanced. 本发明属于生物医药技术领域，具体涉及一种PTH诱导培养的骨髓间充质干细胞(BMSC)在制备颞下颌关节炎治疗药物中的用途。本发明的有益效果在于PTH能显著提升BMSC的增殖能力，并且提高其对活性氧和乏氧的耐受性，PTH诱导培养的骨髓间充质干细胞具备开发成治疗颞下颌关节炎药物的潜力，最终增强BMSC对TMJOA的治疗效果。