Application of fibroin fusion protein in preparation of skin injury external product

• Main Authors: GUAN TUCHEN, LIU YAN, LIU MEI, GU XIAOSONG, YAN YINGYING
• Format: Patent
• Language: Chinese; English
• Published: 24.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses application of fibroin fusion protein in preparation of skin injury external products. The fibroin fusion protein is formed by combining a neurotrophic factor NT-3 and a fibroin light chain through a section of flexible linker chain, the fibroin fusion protein can be self-assembled with silk fibroin to form a novel material capable of playing a stable role for a long time and repairing skin injury, and the material can inhibit inflammation, promote three-type collagen deposition and repair skin injury. Hair follicle regeneration is promoted, and scar-free healing of wounds is achieved. 本发明公开了丝素融合蛋白在制备皮肤损伤外用产品中的应用。所述的丝素融合蛋白是通过一段柔性linker链将神经营养因子NT-3与丝素轻链结合构成，该丝素融合蛋白可与丝素蛋白发生自组装，形成一种能长时间发挥稳定作用的修复皮肤损伤的新型材料，此材料能够抑制炎症，促进三型胶原沉积，促进毛囊新生，使伤口无疤痕愈合。