Initial burst release controlled depot compositions and methods thereof

The present invention relates to a depot composition comprising a hydrophobic amino acid in microspheres, the depot composition being capable of controlling the initial burst release of an excessive amount of an active ingredient in a formulation comprising a biodegradable polymer and the active ing...

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Bibliographic Details
Main Authors LEE EUN JU, LIM DEOK-SU
Format Patent
LanguageChinese
English
Published 21.11.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to a depot composition comprising a hydrophobic amino acid in microspheres, the depot composition being capable of controlling the initial burst release of an excessive amount of an active ingredient in a formulation comprising a biodegradable polymer and the active ingredient, having excellent suspension ability, and being capable of uniformly and continuously obtaining the effect of the active ingredient, even when a common user uses the composition as a formulation for injection. 本发明关于贮库组合物，其包括在微球中的疏水性氨基酸，该贮库组合物能够控制包括生物可降解聚合物及活性成分的调配物中的初期突发释放过量的活性成分、具有优异的悬浮能力、且能够均匀地及连续地获得该活性成分的效应，即使当普通的使用者使用该组合物作为注射用调配物时。
Bibliography:Application Number: CN202180087097