Compositions and methods for targeting inflammatory cells or activating cells and treating or ameliorating inflammatory disorders and pain

• Main Authors: MILLER YURI, CHOI SU-HO
• Format: Patent
• Language: Chinese; English
• Published: 17.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Methods are provided for modifying amino acid sequences and increasing the expression level of ApoA-I binding proteins for the treatment of neuropathic pain, CNS inflammation, hyperalgesia, pain after nerve injury, post-surgical pain, chemotherapy-induced peripheral neuropathy, neurodegeneration, neurotoxicity, neurotoxicity, and the like. Including, for example, neurodegenerative diseases or disorders such as Alzheimer's disease, hyperalgesia, primary headache such as migraine and cluster headache, glaucoma or other ocular inflammatory diseases, pulmonary inflammation, asthma, HIV infection, vascular inflammation, atherosclerosis, and cardiovascular diseases. Provided are methods comprising administering a pharmaceutical composition comprising a recombinantly modified APOA1BP polypeptide to treat neuropathic pain, hyperalgesia, hyperalgesia, neurodegenerative disease, primary headache such as migraine, glaucoma, pulmonary inflammation and asthma, acute respiratory distress syndrome (ARDS), sepsis, viral infe