Adenosine derivative having antagonistic effect on A2A and A3 adenosine receptors and preparation method thereof

The present invention relates to: an adenosine derivative capable of functioning as an antagonist for A2A and A3 adenosine receptors by introducing substituents to No.2 and No.8 carbons and No.6 and/or No.9 amines; a pharmaceutical composition comprising the same; and a method for preparing the same...

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Bibliographic Details
Main Authors JANG SU-JUNG, KIM SEO-HYUN, BYUN JOON-SEOK, KANG JI YOON, KIM JI-WON, CHOI JONG-YEOL, LEE HYUK WOO, JI SEUNG-HEE, SON SEO-HYUN, AN SANG-YUP
Format Patent
LanguageChinese
English
Published 17.11.2023
Subjects
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Summary:The present invention relates to: an adenosine derivative capable of functioning as an antagonist for A2A and A3 adenosine receptors by introducing substituents to No.2 and No.8 carbons and No.6 and/or No.9 amines; a pharmaceutical composition comprising the same; and a method for preparing the same. The adenosine derivative can effectively prevent or treat brain diseases, cardiovascular diseases, sleep disorders, inflammation, immune system diseases and the like related to an A2A or A3 adenosine receptor by adjusting the activity of the A2A or A3 adenosine receptor. 本发明涉及一种通过在2号、8号碳和6号和/或9号胺导入取代基而能够起到A2A及A3腺苷受体的拮抗剂作用的腺苷衍生物、包含其的药物组合物及其制备方法，所述腺苷衍生物可通过调节A2A或A3腺苷受体的活性来有效预防或治疗所述受体相关的脑部疾病、心血管疾病、睡眠障碍、炎症及免疫系统疾病等。
Bibliography:Application Number: CN202280024999