Freeze-drying preparation as well as preparation method and application thereof

• Main Authors: HU BOBO, SUN QUN
• Format: Patent
• Language: Chinese; English
• Published: 10.11.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The invention relates to the technical field of medicine, in particular to a freeze-dried preparation and a preparation method and application thereof, the freeze-dried preparation comprises fosaprepitant or pharmaceutically acceptable salt thereof and human serum albumin, and the weight ratio of fosaprepitant or pharmaceutically acceptable salt thereof to human serum albumin is 1: 0.2-1: 2. The freeze-dried preparation can further comprise palonosetron or a pharmaceutically acceptable salt of the palonosetron, a freeze-dried excipient and a pH value regulator. 本发明涉及医药技术领域，具体的，提供一种冻干制剂及其制备方法和应用，该冻干制剂包括福沙匹坦或其药学上可接受的盐和人血清白蛋白，福沙匹坦或其药学上可接受的盐与人血清白蛋白的重量比为1：0.2至1：2。该冻干制剂还可以进一步包括帕洛诺司琼或其药学上可接受的盐、冻干赋形剂和pH值调节剂。