Preparation method of tefuryltrione and intermediate thereof

The invention relates to a preparation method of furan sulcotrione and an intermediate thereof, which comprises the following steps: directly brominating 2-chloro-3-methyl-4-(methylsulfonyl) benzoic acid serving as a raw material to obtain 2-chloro-3-bromomethyl-4-(methylsulfonyl) benzoic acid; then...

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Bibliographic Details
Main Authors SHEN YUNHE, YIN BO, ZHU YUCHAO
Format Patent
LanguageChinese
English
Published 10.11.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a preparation method of furan sulcotrione and an intermediate thereof, which comprises the following steps: directly brominating 2-chloro-3-methyl-4-(methylsulfonyl) benzoic acid serving as a raw material to obtain 2-chloro-3-bromomethyl-4-(methylsulfonyl) benzoic acid; then, 2-chloro-3-bromomethyl-4-(methylsulfonyl) benzoic acid and tetrahydrofurfuryl alcohol are subjected to a substitution reaction, and 2-chloro-4-(methylsulfonyl)-3-(((tetrahydrofuran-2-yl) methoxy) methyl) benzoic acid is obtained; then carrying out acylating chlorination on the intermediate; carrying out condensation reaction on the acyl chloride intermediate and cyclohexanedione under the action of triethylamine; and finally, adding acetone cyanohydrin serving as a catalyst, and carrying out rearrangement reaction to obtain the target product tefuryltrione. Compared with the prior art, the preparation method has the advantages that esterification protection of the raw material 2-chloro-3-methyl-4-methylsulfonyl b
Bibliography:Application Number: CN202310870855