Topological modification of interleukin-2 and application of interleukin-2 as autoimmune disease medicine
The invention discloses topological transformation of interleukin-2 and application of the interleukin-2 as an autoimmune disease medicine. According to the invention, the interleukin-2 is subjected to topological transformation, so that the interleukin-2 with a cyclic or isohydrocarbon topological...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
07.11.2023
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention discloses topological transformation of interleukin-2 and application of the interleukin-2 as an autoimmune disease medicine. According to the invention, the interleukin-2 is subjected to topological transformation, so that the interleukin-2 with a cyclic or isohydrocarbon topological structure of targeted activated Treg is obtained. The affinity of the interleukin-2 with the cyclic or Soxhlet-hydrocarbon structure and a receptor is not changed, the half-life period of the medicine can be prolonged, the stability can be enhanced, the dosage of long-term medication and the medication frequency can be reduced, and the effect of inhibiting immunity can be achieved. As a long-acting immunosuppressor, the interleukin-2 topological transformation protein disclosed by the invention is beneficial to treatment of various autoimmune diseases.
本发明公开了白细胞介素-2的拓扑改造及其作为自身免疫病药物的应用。本发明对白细胞介素-2进行拓扑改造,获得了靶向性激活Treg的环状或索烃拓扑结构的白细胞介素-2。环状或索烃结构的白细胞介素-2不改变其与受体的亲和性,同时可以延长药物的半衰期,增强稳定性,减少长期用药的剂量和用药次数,发挥抑制免疫的效果。本发明的白细胞介素-2拓 |
---|---|
Bibliography: | Application Number: CN202310827760 |