Cationic lipid compound as well as preparation method and application thereof

• Main Authors: HAN LONG, LIU CHANGSHENG, HU YALING, ZHAO DAN, LI CHUNYI, MENG LINGJUN, HU JIN, CUI GUOLIANG
• Format: Patent
• Language: Chinese; English
• Published: 07.11.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; STEROIDS

The invention provides a cationic lipid compound as well as a preparation method and application thereof. The cationic lipid compound has a structure as shown in a formula I. The cationic lipid compound provided by the invention is simple in chemical structure and easy to synthesize, and can be used for preparing a drug carrier, especially a nucleic acid drug carrier. The drug-loaded lipid nanoparticles containing the cationic lipid compound are small in particle size and uniform in particle size distribution, and have a good loading effect and a good delivery effect on nucleic acid drugs. # imgabs0 # 本发明提供了一种阳离子脂质化合物及其制备方法和用途。所述阳离子脂质化合物具有式I所示结构。本发明提供的阳离子脂质化合物化学结构简单，易合成，可用于制备药物载体，特别是核酸药物载体。含有该阳离子脂质化合物的载药脂质纳米颗粒粒径小，粒径分布均一，对核酸药物具有良好的负载效果和递送效果。#imgabs0#