Peptide with anti-aging effect as well as composition and application thereof

• Main Authors: DING WENFENG, ZHAO WENHAO, PENG YAN, XIAO YU, CHEN XUE, SUN XINLIN, GUAN FUYI
• Format: Patent
• Language: Chinese; English
• Published: 03.11.2023
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS

The present invention provides a peptide having formula (I) R1-Ser-Pro-X1-Gln-R2, or a cosmetically or pharmaceutically acceptable salt thereof, or a cosmetic composition or pharmaceutical composition thereof, and their use in the preparation of a composition for treating, preventing or repairing skin aging or photoaging, promoting collagen production, increasing skin elasticity and/or skin compactness, and for treating, preventing or repairing skin aging or photoaging. The invention also relates to application of the compound in a cosmetic composition or a pharmaceutical composition for promoting PER1 protein expression, regulating skin circadian rhythm and/or repairing damaged skin cells. The peptide of the formula (I) can relieve skin aging signs by activating expression of skin circadian rhythm cycle regulating genes and related proteins, regulating skin circadian rhythm and resynchronizing skin cell biological clocks, enhancing cell viability and repairing damaged cells, can be used for resisting skin ag