Methods for identifying LILRB blocking antibodies

• Main Authors: ZHANG CHENGCHENG, HUANG RICHARD, WU GUOJIN, AN ZHIQIANG, KIM JAE-HYUP, DENG MI, ZHANG NINGYAN, CHEN HEYU
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Provided herein are methods and compositions for identifying modulators of LILRB3 activation. Also provided herein are methods of treating cancer comprising administering an inhibitor of LILRB3 activation. Also provided are methods of treating an autoimmune disease or inhibiting graft rejection attack or treating an inflammatory condition comprising administering to a subject an LILRB3-activated agonist. 本文提供了用于鉴定LILRB3活化的调节剂的方法和组合物。本文还提供了治疗癌症的方法，所述方法包括施用LILRB3活化的抑制剂。还提供了治疗自身免疫性疾病或抑制移植物排斥发作或治疗炎性病症的方法，所述方法包括向受试者施用LILRB3活化的激动剂。