Treatment of pathological fatigue with oxaloacetate

• Main Author: CASH ANDREW B
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure relates to therapeutic methods and compositions for treating pathological fatigue caused by injury or disease of the body. Pathological fatigue refers to physical and mental fatigue caused by viral infection, bacterial infection, trauma, disease or gene alteration, which leads to fatigue that cannot be ameliorated by lying in bed and may deteriorate due to physical or mental activities. Such pathological fatigue occurs in myalgia encephalomyelitis (ME)/chronic fatigue syndrome (CFS) and other disorders, such as post-COVID-19 fatigue, post-viral fatigue, fibromyalgia (FM), cancer, Parkinson's disease, other diseases and trauma, and combinations thereof. Related methods of treatment and pharmaceutical compositions are also disclosed. 本公开文本涉及用于治疗由身体的损伤或疾病引起的病理性疲劳的治疗方法和组合物。病理性疲劳是指由病毒感染、细菌感染、创伤、疾病或基因改变引起的身体和精神疲劳，其导致不能通过卧床休息而改善并可能因身体或精神活动而恶化的疲劳。此类病理性疲劳发生在肌痛性脑脊髓炎(ME)/慢性疲劳综合征(CFS)和其他障碍，如COVID-19后疲劳、病毒后疲劳、纤维肌痛(FM)、癌症、帕金森病、其他疾病和创伤以及其组合中。还公开了相关的治疗方法和药物组合物。