Garlicin derivative as well as preparation method and application thereof

• Main Authors: LIAO LIQUN, CHEN TINGZHUO, HE QIMING, WANG ZHOUYU, ZHOU HAIWEI, YANG LINGLING, ZHU HONGJIANG, ZHAO WENJUAN, LI ZHENZHEN, LI LAN, REN DAN
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

The invention discloses an allicin derivative and a preparation method and application thereof, the structural formula of the allicin derivative is # imgabs0, R1 is a substituted or unsubstituted group selected from the following groups: phenyl, nitrogen heterocyclic aryl, sulfur heterocyclic aryl, naphthenic base, fused ring aryl, benzopyranyl, epoxy alkyl, pyrimidyl and morpholino nitrogen; the substitution refers to substitution of one or more groups selected from the following groups: fluorine, chlorine, bromine, alkoxy, amino, halogenated alkoxy, alkylsulfonyl, nitrile group, benzyloxy, nitryl, aminosulfonyl and phenyl; when R2 exists, R2 is hydrogen or methyl; when R3 exists, R3 is oxygen, and the number of oxygen is 2 or 4; r2 and R3 do not exist at the same time. The allicin derivative disclosed by the invention has a relatively good control effect on pathogenic bacteria which generate drug resistance to existing bactericides, and is high in antibacterial activity and wider in antibacterial spectrum.