Continuous preparation method, device and system of p-acetamidobenzene sulfonyl chloride

• Main Authors: ZOU HAIKUI, LIU LIMING, XIAO GUANGHUI, CHEN JIANFENG, LIU SHIHAO, LUO YONG, CHU GUANGWEN, FU JIWEN, SUN BAOCHANG, MI JIANBIN, NIU SHENGCAO
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses a continuous preparation method of p-acetamidobenzene sulfonyl chloride, which comprises the following steps: by taking liquid acetanilide and chlorosulfonic acid as raw materials, continuously inputting the liquid acetanilide and chlorosulfonic acid into a supergravity reactor for reaction, then introducing into a stirring kettle for secondary reaction, and carrying out chlorination treatment on the reaction product to obtain the p-acetamidobenzene sulfonyl chloride. The supergravity device is adopted as the sulfonation reactor, local hot spots in the reaction process are avoided by strengthening mixing and mass transfer of materials, the product yield is high, a pressure sensor is arranged in the supergravity reactor, continuity of the sulfonation process is achieved, whole-process automatic interlocking control can be achieved, technological parameters can be precisely regulated and controlled, the reaction device is remarkably reduced, and the production cost is reduced. And the de