Preparation method of novel degradable urinary system tissue engineering substitute

• Main Authors: MA PEIFEN, ZHAO HAN, HU JINGLONG, LI DANQIAN, ZHAO GUANGHUI, LI MENGYUN, WANG ZHIPING, LI LINGYAN
• Format: Patent
• Language: Chinese; English
• Published: 27.10.2023
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention discloses a preparation method of a novel degradable urinary system tissue engineering scaffold material. The preparation method comprises preparation of levofloxacin-loaded chitosan and preparation of the degradable tissue engineering scaffold material. The preparation method has the beneficial effects that the levofloxacin is loaded in the chitosan, so that the antibacterial effect of the levofloxacin is enhanced, and the problem of wound infection after the tissue engineering scaffold material is implanted can be prevented. According to the invention, the chitosan scaffold loaded with levofloxacin is taken as a substrate, and PLGA and I-type collagen are taken as a scaffold coating, so that the overall biocompatibility and degradation performance of the tissue engineering scaffold material are ensured; besides, the tissue engineering scaffold material disclosed by the invention is of a three-dimensional network structure, so that the ingrowth of cells and new blood vessels is facilitated, and