CONNECTOR FOR ANTIBODY-DRUG CONJUGATE AND APPLICATION THEREOF

• Main Authors: FANG JIANMIN, YE HUI, CHEN HU, HUANG CHANGJIANG, SHEN NAN, LUO WENTING, ZHAN XIUZHI, HOU QIAOHUA
• Format: Patent
• Language: Chinese; English
• Published: 24.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a connexon for preparing an antibody conjugate, an antibody drug conjugate prepared from the connexon, and application of the connexon in drugs for treating tumors. The linker can be simultaneously coupled with an antibody or sulfydryl or amino on a functional fragment of the antibody, especially can be coupled with 2, 3 or 4 sulfydryl of the functional fragment of the antibody, and the coupled product is uniform and stable in structure. 一种用于制备抗体偶联物的连接子以及由该连接子制备的抗体药物偶联物，以及其在治疗肿瘤药物中的用途。所述的连接子可同时与抗体或者抗体的功能片段上的巯基或者氨基偶联，尤其是能够与抗体功能片段的2、3或4个巯基偶联，偶联后的产物均一、结构稳定。