Membrane bionic nano-drug, preparation method and application

• Main Authors: LIU BIN, ZHOU QING, UMEMI, DAI JINGJING, DENG ZHE, TIAN XUEFEI
• Format: Patent
• Language: Chinese; English
• Published: 24.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The invention belongs to the technical field of targeted anti-tumor drugs, and particularly relates to a membrane bionic nano-drug, a preparation method and application, the membrane bionic nano-drug comprises aloe-emodin, PLGA, PVA and a hybrid membrane, and the hybrid membrane is obtained after a HepG2 cell membrane and a RAW 264.7 cell membrane are fused; the preparation method comprises the following steps: dissolving aloe-emodin and PLGA (poly (lactic-co-glycolic acid)) in a dimethyl sulfoxide solvent, then dropwise adding the solution into a polyvinyl alcohol aqueous solution subjected to ultrasonic treatment, and removing dimethyl sulfoxide to obtain AE-coated PLGA NPs; the AE-coated PLGA NPs and the hybrid membrane are mixed, membrane extrusion is adopted, and the membrane bionic nano-drug is obtained and used for improving the anti-tumor effect and the targeting effect of the aloe-emodin. 本发明属于靶向抗肿瘤药物技术领域，具体涉及一种膜仿生纳米药物、制备方法和应用，包括芦荟大黄素、PLGA、PVA和杂化膜，所述杂化膜为HepG2细胞膜和RAW 264.7细胞膜融合后得到；制备方法为，将芦荟大黄素和PLGA溶解在