NOVEL MODIFIED REOVIRUS AND USES THEREOF

• Main Authors: LIU XINGJUN, SONG KI-HUN, LEE YEONSOOK, HAN XIANGQING
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a modified reovirus and a use thereof, and has proved that a novel modified reovirus derived from a wild-type reovirus not only has a good anti-cancer effect on various cancers, including rare cancers, but also can enhance the effect of a cancer immunotherapeutic agent. In particular, it has been demonstrated that the modified reovirus according to the present invention can significantly reduce the cell viability of all cancer cell lines when used in the treatment of various types of cancer cells, including rare cancers such as melanoma and tongue cancer, in particular, has a good anti-cancer effect even for cancer cell lines that are resistant to taxane-based anti-cancer drugs. Furthermore, the modified reovirus according to the present invention exhibits a dose-dependent anti-cancer effect of an independent administration route even in a mouse model of melanoma, bladder cancer, and oral cancer, and exhibits a further improvement in anti-cancer effect when administered repeat