Humanized mouse model for assessing immune cell therapy

• Main Authors: JIAO JIAO, YE CHUNTING, KECK JURGEN
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2023
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; NEW BREEDS OF ANIMALS; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; TRAPPING

Provided herein are humanized mouse models and methods for determining whether administration of an engineered immune cell therapy is likely to elicit cytokine release syndrome and/or determining the efficacy of an anti-disease therapy. In addition, the models provided herein can be used to test the efficacy of different anti-CRS therapies. 本文提供了人源化小鼠模型和用于确定工程化免疫细胞疗法的施用是否可能引发细胞因子释放综合征和/或确定抗疾病疗法的功效的方法。此外，本文提供的模型可用于测试不同的抗CRS疗法的功效。