FimH mutants, compositions and uses thereof

• Main Authors: FEITSMA, LEONARD, J, GRIJPSTRA, JEROEN, FAY KEVIN C, GEURTSEN, JENS, WEIDENBERG ETHAN MARTIN
• Format: Patent
• Language: Chinese; English
• Published: 13.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention describes a polypeptide comprising a FimH lectin domain, the FimH lectin domain comprising at least one amino acid mutation that results in the FimH lectin domain being in a conformation that is low in affinity for mannose. Also described are pharmaceutical compositions comprising such polypeptides and methods of stimulating an immune response in a subject in need thereof by administering the polypeptides. 本发明描述了包含FimH凝集素结构域的多肽，该FimH凝集素结构域包含导致该FimH凝集素结构域呈对甘露糖低亲和力的构象的至少一个氨基酸突变。还描述了包含此类多肽的药物组合物和通过施用该多肽在有需要的受试者中刺激免疫应答的方法。