Preparation process of high-purity 2, 6-difluorobenzamide

• Main Authors: LIU HUAZHEN, SHAN YONGXIANG, CHEN BAOMING, ZHANG LEI, WEI ZIQIANG, YIN FENGSHAN, YIN PING, WANG JINYANG, LEI HAINING
• Format: Patent
• Language: Chinese; English
• Published: 10.10.2023
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to a preparation process of high-purity 2, 6-difluorobenzamide, which comprises the following steps: by taking 2, 6-difluorobenzonitrile as a raw material, adding water and a quaternary ammonium salt phase transfer catalyst to form a mixed solution, simultaneously dropwise adding hydrogen peroxide and an inorganic alkali solution into the solution, controlling the simultaneous dropwise adding to be finished, and keeping the temperature until the reaction is finished; cooling, crystallizing and filtering to obtain a 2, 6-difluorobenzamide crude product; and pulping the crude product with water, filtering and drying to obtain a 2, 6-difluorobenzamide product. The process provided by the invention has the advantages of high content, high yield, less three wastes, strong safety and the like, is a green process with high selectivity, strong economy and environmental friendliness, and has great guiding significance for industrial production. 一种高纯度2,6-二氟苯甲酰胺的制备工艺，该制备工艺以2,6-二氟苯腈为原料，加入水和季铵盐相转移催化剂