Beta-carotene solid dispersion and preparation method thereof

• Main Authors: LIU MIN, LI YINGLAN, WANG ZHENGPING, DING ZHUANG, ZHANG HUAIZHEN, ZHAO YANNA
• Format: Patent
• Language: Chinese; English
• Published: 10.10.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a beta-carotene solid dispersion and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The preparation method comprises the following steps: mixing beta-carotene, a polymer carrier material and Span 20, adding an organic solvent for dissolving, and drying to obtain the beta-carotene solid dispersion. The beta-carotene and the polymer carrier material form the solid dispersion, so that the beta-carotene is kept in a highly dispersed state, the beta-carotene bulk drug exists in a microcrystal state, an amorphous state, a colloidal dispersed state or a molecular dispersed state, the dispersion degree is high, the dissolution speed of the beta-carotene is increased, and the bioavailability of the beta-carotene is improved. The absorption of beta-carotene can be promoted, and the bioavailability is improved. 本发明提供了一种β-胡萝卜素固体分散体及其制备方法，属于药物制剂技术领域。本发明将β-胡萝卜素、高分子载体材料和司盘20混合，加入有机溶剂溶解，干燥，得到所述的β-胡萝卜素固体分散体。本发明将β-胡萝卜素与高分子载体材料形成固体分散体，使β-胡萝卜素保持高度分散状态，β-胡萝卜