Diagnosis and characterization of infections using diffusion and relaxation edited proton NMR spectra

Provided herein are 1H-NMR spectroscopy molecular markers for the identification of medical risk markers such as SARS-CoV-2 infection, acute inflammation, or cardiovascular risk conditions. The labeling uses a combination of NMR intensity signals comprising a Glyc signal from at least one N-acetyl (...

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Bibliographic Details
Main Authors NICHOLSON JAY K, WEST JOHN, NITSCHKE, PETER, REINSPERGER THOMAS, HOLMES, ERIC, RU DEGE, STEFAN, BERMEIER WOLFGANG
Format Patent
LanguageChinese
English
Published 03.10.2023
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Provided herein are 1H-NMR spectroscopy molecular markers for the identification of medical risk markers such as SARS-CoV-2 infection, acute inflammation, or cardiovascular risk conditions. The labeling uses a combination of NMR intensity signals comprising a Glyc signal from at least one N-acetyl (-NCOCH3) glycoprotein and an SPC signal from the choline head group (+ N-(CH3) 3) of a supramolecular phospholipid cluster (SPC) present in the HDL and LDL lipoprotein sub-fractions. The Glyc signal is in a chemical shift region of # = 2.00 ppm to # = 2.20 ppm, and includes a signal GlycA (2.00 ppm to 2.09 ppm) and a signal GlycB (2.09 ppm to 2.2 ppm). The SPC signal is in a chemical shift region of # = 3.20 ppm to # = 3.30 ppm, and includes a signal SPC1 (3.2 ppm to 3.235) ppm, a signal SPC2 (3.235 ppm to 3.26 ppm), and a signal SPC3 (3.26 ppm to 3.3 ppm). Also provided herein are systems for identifying markers. 本文提供1H-NMR谱分子标记用于鉴定医学风险标志比如SARS-CoV-2感染，急性炎症或心血管风险病况。该标记使用NMR强度信号的组合，包括来自至少一种N-乙酰基(-NCOCH3)糖蛋白的Glyc信号和
Bibliography:Application Number: CN202280010139